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Research Articles

Aminocaproic Acid Reduces Blood Loss after Bilateral Total Hip Arthroplasty

Author: Harrison M Lands

Introduction: This retrospective case control study aims to evaluate the efficacy of the antifibrinolyticaminocaproic acid in patients undergoing bilateral simultaneous Total Hip Arthroplasty (THA). Materials and Methods: A total of 148 hips (74 patients) underwent simultaneous bilateral total hip arthroplastieswith 29 receiving Acetylsalicylic Acid (ASA) only and 45 receiving Aminocaproic Acid (ACA) withASA depending on when the surgery was performed at our institution. Results: Demographics were similar between groups as measured by average Body Mass Index (BMI), age, and gender, and there was no significant difference in length of stay or duration of operation between the two groups. Patients given aminocaproic acid had a significantly decreased change in hemoglobin on post-operative day one (p<0.00034) and significantly decreased changebetween pre-operative and minimum post-operative hemoglobin duringhospitalization (p=0.00011), but no statistically significantdifference in transfusion rate (p=0.893). Additionally, patients given aminocaproic acid had significantly less total drain output throughout their hospital stay. Conclusion: When compared to ASA alone, among patients undergoing simultaneous bilateral THA, the addition of ACA significantly decreased the change in hemoglobin post-operatively on day one and between pre-operative and minimum post-operative hemoglobin, and reduced total drain output.
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